Autoantibodies Definitions:
- an immunoglobulin produced by a person that recognizes an antigen on that person’s own tissues.
- An antibody derived from the immune system, which then acts against body tissues or constituents.
- Antibody occurring in response to antigenic constituents of the host’s tissue, and which reacts with the inciting tissuecomponent.
- an antibody formed in response to, and reacting against, an antigenic constituent of the individual’s own tissues.
Autoantibodies examples with resulting diseases
1. Antiphospholipid syndrome >>
- Anti-beta2 glycoprotein: increased thrombosis (arterial or venous) or spontaneous abortion from placental clots, strokes, hepatic vein clots
- lupus anticoagulant = hypercoagulation!
- anticardiolipin
2. Autoimmune hepatitis type 1 >> Anti-smooth muscle
3. Bullous pemphigoid>>Anti-hemidesmosome
4.Celiac disease>>
- IgA anti-endomysial
- IgA anti-tissue transglutaminase
5. Diffuse Scleroderma >> anti-Scl-70 antibody (anti-DNA topoisomerase)
6. Drug-induced lupus>> Anti-histone
7. Goodpasture syndrome>>Anti-glomerular basement membrane
8.Granulomatosis with polyangiitis >> PR3-ANCA / c-ANCA
9. Graves disease>> Anti-TSH receptor (activates it)
10. Hashimoto thyroiditis >>
- Antimicrosomal
- Antithyroglobulin
- Anti-thyroid peroxidase (TPO)
11.Lambert-Eaton myasthenic syndrome > Anti-presynaptic voltage-gated calcium channel
12. Limited scleroderma (CREST syndrome)>> Anticentromere
13.lupus >>
- Anticardiolipin
- Lupus anticoagulant
- SPECIFIC: Anti-smith and anti-dsDNA abs
- Anti nuclear bodies
- Anti-histones: Rx-induced
13. Mixed connective tissue disease >> Anti-U1 RNP (ribonucleoprotein)
14. Myasthenia gravis>>Anti-ACh receptor (blocks receptor)
15. Often associated with SLE (nonspecific)>> Antinuclear (ANA)
16. Pemphigus vulgaris>> Anti-desmoglein
17. Pernicious anemia>>Antiparietal cell ,,Anti-intrinsic factor
18. Polymyositis ,,Dermatomyositis >>
- Antisynthetase (anti-Jo-1)
- Anti-SRP
- Anti-helicase (anti-Mi-2)
19. Primary biliary cirrhosis >> Antimitochondrial
20.Primary membranous nephropathy>>
- Antiphospholipase A2 receptor
- 85% of membranous nephropathy
21. Rheumatoid arthritis>>
- Rheumatoid factor (IgM against IgG Fc region)
- Anti-CCP (more specific)
22. Scleroderma (diffuse) >> Anti-Scl-70 (anti-DNA topoisomerase I)
23. Sjogren’s syndrome>>
- Anti-SS-A (Anti-Ro)
- Anti-SS-B (Anti-La)
24. SLE>>>
- Anti-dsDNA
- Anti-smith
25.Type 1 DM>>
- Anti-glutamic acid decarboxylase (GAD)
- Anti-islet cell cytoplasmic antibodies
26. VASCULITIS>> MPO-ANCA / p-ANCA
- Microscopic polyangiitis
- Eosinophilic granulomatosis with polyangiitis
- Ulcerative colitis
27. Wegener’s granulomatosis>>
- c-ANCA
- vasculitis: necrotizing granulomas of lung & necrotizing glomerulonephritis
Flash cards for Autoantibodies:
