Mnemonics and Summary for Lidocaine (local anesthetic)
Mnemonic (In General) for LIDOCAINE :
LIDOCAINE
L– local anasthetic
I– ICU popular antiarrythmic
D– digitalis toxicity used
O– orally inactive
C– cinetidine+ propanolol
A– decrease Automacity
I– inactivated Na Channel blocker
N– nystagmus
E– eye blurred vision, ECG change
Mnemonic for toxicity of LIDOCAINE :
SAMS
Indications:
- Rapid acting local anesthetic for procedures ranging from infiltration to regional nerve block
- Antiarrhythmic in the treatment of vent. arrhythmias
- Treatment of status epilepticus (INVESTIGATIONAL)
- Treatment of pain >>Operative >>Neuropathic pain
> common route of administration >> IV ,, Topical ,, Dermal patch ,, Nasal spray.
Action on CNS & CVS:
MOA:
Alters depolarization in neurons by blocking the fast voltage gated sodium (Na+)channels in the cell membrane.
PHARMACOKINETICS:
**Absorption>>Absorbed rapidly after parenteral administration & from GIT & Respiratory Tract
**Metabolism>> Metabolized in the liver
**Excretion>>Metabolites and unchanged drug are excreted by the kidneys in the urine
Toxicity & Overdose:
- Seizures
- Altered central nervous system
- Muscle twitching
- Slurred speech
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