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Definition
Gout Is a true crystal deposit disease(monosodiom urate crystals).it may present as acute arthritis,bursitis,tenosynovitis,cellulitis or tophaceous deposit .
Prolonged hyperuricemias necessary but alone is not enough to develop gout
Types of gout
Primary gout
Secondary gout
Etiology
1/3 of body uric acid pool is derrived from diet 2/3 of body uric acid pool is from endogenous purine metabolism.
Elemination of uric acid by the kidney (2/3) and gut (1/3)
Xanthine oxidase enzyme catalyses the end conversation of hypoxanthine to xanthine and to uric acid
Risk factors
1- hyperuricemia
2-obesity
3-high alcohol intake
4-hypertension
5- IHD
6-inhereted alteration of tissue factors
Clinical features
1-acute gouty arthritis
2-intercritical
3-Chronic
4-Urolithiasis
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